|The world-wide spread of antibiotic-resistant microorganisms can be viewed as an ecological consequence of the systematic use of antimicrobial agents. Resistant bacteria prevail in healthcare environments where antibiotic selective pressure is intensive.|
Novel therapeutic approaches are urgently required to deliver the well-documented existing drugs to
i) protect them toward degradation
ii) increase their bioavailability
iii) reduce toxic side effects
iv) increase patient compliance and
iv) reduce treatment duration and related costs.
In this sense, nanocarriers based on cyclodextrins (CDs) are particularly appealing for the delivery of antibiotics, an approach of main interest for tuberculosis (TB), infections related to Salmonella typhimurium, Staphyloccocus aureus and for species most frequently implicated in hospital infections such as enteric gram-negative rods. The CycloN Hit project takes advantage of the high level interdisciplinary expertise of the partners to efficiently encapsulate and protect antibiotics in CD-based nanocarriers to combat resistant bacteria. This will be accomplished through research training of 11 Early Stage and 5 Experienced Researchers who will gather expertise of 11 Full and 6 Associated partners. The final goal is to bring to the preclinical studies an antibiotic formulation for the treatment of TB and more tailored alternative therapeutic approaches for other resistant microorganisms.
April 2, 2017
For a summary of Cyclon Hit awards click here.
For a summary of Cyclon Hit Outreach Activities click here
March 20, 2017
The next Cyclon Hit Workshop-4 will be held during May 3-4, 2017 in Gothenburg, Sweden on "Optical microscopy in life science - from basics to state of the art"
Wallenberg Conference Centre, University of Gothenburg, Medicinaregatan 20A
March 2, 2017
The drug-resistant bacteria that pose the greatest health threats: Read the article and see the "Threat list" in Nature/News of this week. The article describes "The list that ranks 12 bacteria or bacterial families is topped by carbapenem-resistant Acinetobacter baumannii...Antibiotic resistance kills an estimated 700,000 people each year worldwide, and some experts predict that number to reach 10 million by 2050 if efforts are not made to curtail resistance or develop new antibiotics".
March 2, 2017
UPCOMING CycloN Hit EVENT
Workshop: "Optical microscopy in life science - from basics to state of the art". May 3-4, Gothenburgh, Sweden. Details to be announced soon.
February 25, 2017
The 5th European Cyclodextrin Conference (EUROCD 2017) will take place in Lisbon, Portugal, October 3 - 6, 2017.
Abstract submission deadline: Wednesday, April 14th 2017, 23:59 [UTC+00:00].
"The EuroCD 2017 will provide an opportunity for scientists working in cyclodextrin research to meet and discuss recent advances in this field. We aim to provide a positive environment for PhD students, early career scientists and senior researchers to create and strengthen their work collaborations".Chair, Organizing Committee: prof. Helena Cabral Marques, U. of Lisbon.
February 10, 2017
The January issue of Cyclodextrin News deals with the role of cyclodextrins in quorum sensing (QS), a mechanism that makes possible for a population of bacteria to behave as a multi-cellular organism in host colonization. The article is written by Dr. Eva Fenyvesi, Cyclolab SA.
December 4, 2016
The latest issue of Cyclodextrin News reviews the recent research literature on the role of Cyclodextrins in autophagy, in an article written by Dr. Eva Fenyvesi (partner CycloLab). The article includes a review on the effects of Cyclodextrins in the antibacterial and antiviral defense mechanism.
November 5, 2016
PhD student position in Biomedical Photonics in the group of prof. Marica Ericson. Desired qualification of the applicant is a degree in physics / chemistry / biophysics or similar. More information and application can be found at:
October 1, 2016
POST DOCTORAL POSITION: The National Center for Scientific Research (CNRS), Institute of Molecular Sciences of Orsay (ISMO)/
Université Paris-Sud, Orsay, France is seeking a suitable candidate to fill a one-year Post-Doctoral Position for the CycloN-Hit project in the subject "Engineered nanoparticles to fight severe infections".
Click here for details.
July 30, 2016
György Kéri passed away
Professor György Kéri, CEO of associated partner Vichem Ltd, passed away on July 20th, 2016 at the age of 66 after a long fight against an incurable disease. Professor Kéri was a world-wide recognized biochemist and a Professor of Semmelweis University. His outstanding research in the field of cell signaling therapy and related pharmaceuticals made him famous among professionals. He developed several kinase inhibitors for clinical trials including sunitinib, which was approved by FDA for the treatment of renal cell carcinoma and imatinib-resistant gastrointestinal stromal tumor in 2006. Sunitinib was the first cancer drug simultaneously approved for two different indications. Professor Kéri was a member of several national and international biotechnology organizations and editor of Current Signal Transduction Therapy and of Current Opinion in Molecular Therapeutics among others. He founded Vichem in 1999 to develop a kinase inhibitor library and a hit-finding technology called Nested Chemical Library™. At Vichem he has recently developed the DriverHit Library™ for inhibiting the signaling pathways activated by cancer driver genes or mutated tumor suppressor genes. Vichem joined CyclonHit as Associated Partner to share the knowledge on antibiotics against tuberculosis developed by the company. We will miss him.
July 19, 2016
Cyclolab's Cyclodextrin News is published with focus on CDs in environmental technology, as presented in ICS18, May 2016, USA.
June 9, 2016
Visit Cyclolab's Cyclodextrin News, the monthly review of cyclodextrin literature. The editorial of May edition is on "Cyclodextrin for Prevention and Treatment of Atherosclerosis" and reviews research on the potential of HPβCD as a drug. In the same issue titles of the presentations in ICS18, 21-24 May 2016, Gainesville, Florida, USA, can be found.
June 9, 2016
The latest (May 2016) Review on Antimicrobial Resistance Review is a very interesting and highly publishized document in the general press that presents the great threats of AMR and proposes ten measures to be adopted by the public health care system and governments to contain the problem.
May 30, 2016
The 3rd Cyclon Hit Summer School "Photoactivable antibacterials: from basic concepts to practical applications" organised by CycloN Hit partners Dr. I. Manet (CNR, Bologna, Italy) and Prof. S. Sortino (U. Catania, Italy) will be held in CNR Bologna, Italy, September 26-28, 2016. Please click for the Flyer, the 1st Circular with details and the Preliminary program. Registration has no expiry date, but is requested before July 15.
May 6, 2016
The 3rd Cyclon Hit Workshop "From Cyclodextrins to Nanoparticles: Synthesis and Applications" was successfully concluded at the University of Almeria, Spain on April 21st, 2016, organized by Prof. A. Vargas-Berenguel and his group. It comprised interesting topics on cyclodextrin chemistry and bio-applications. Additionally, a complementary skills lecture, "Scientific Writing", by prof. R. Thompson, U. Almeria, was much appreciated by both junior and senior researchers.
April 11, 2016
The 3rd Workshop (see program above) and the next Project Meeting will be held at the University of Almeria, Spain. Both events will be organized by Prof. A. Vargas-Berenguel.
March 20, 2016
Science Festival in Uppsala (Sweden)
Dr. Sabrina Valetti (ER, Nanologica SA) and Hanna Thomsen, (ESR, UGOT) participated in outreach activities, the SciFest http://www.scifest.uu.se/?languageId=1, March 2-5, 2016
The activity “Welcome to the MICRO and NANOworld: the body and the medicines. Are you curious to see how the body tissues appear under the microscope? Have you already heard about the new generation of medicines, the nanoparticles?” was displayed with microscope to visualize particles, videos and powerpoint about nanoparticles and resistant infections. Many primary and high school children visited the two-day event.
March 20, 2016
The 18th International Cyclodextrin Symposium will be held at the University of Florida, Gainesville, Florida, USA, May 18-21, 2016. Visit the web site for further details.
March 20, 2016
The 3rd International Summer School on Cyclodextrins is organized by the Italian Association of Chemistry and Technology of Cyclodextrins during June 29-July 1, 2016 in Asti, Italy.
January 15, 2016
Presentation of CycloN Hit and its activities at the University of Paris-Saclay and CNRS: Fighting antibiotic resistance through nanodrugs: Success of the European project CYCLON HIT at Université Paris-Saclay and at CNRS
December 22, 2015
The last issue of Cyclodextrin News in this year is available.
A novel application field was discovered by the group of Prof. Arima (including also the Szejtli-Prize winner Prof. K. Motoyama): HPBCD was found effective in inhibition of leukemic cell proliferation at various leukemic cell lines. Read the editorial on "HPBCD as Anticancer Drug (Resumé of PlosOne 10(11):e0141946)”.
November 10, 2015
Post Doctoral position is available at NCSR "Demokritos", Athens, Greece. STARTING DATE: January 11, 2016 or according to agreement; DURATION: 12 months; a recent ( ≤5 years research experience, after the MSc degree, at the time of hiring) PhD (doctorate) degree in Chemistry or Pharmaceutical Sciences is required. Click here for details. POSITION CLOSED
October 30, 2015
Summary Report on European Cyclodextrin Symposium (EuroCD), Lille, France, October 6-9, 2015: Dr. Eva Fenyvesi (CycloLab SA) has prepared a summary of interesting presentations on cyclodextrins for delivery of antibiotics.
October 22, 2015
The International symposium "Advances in nanoparticulate carriers: applications in diseases and infections" that took place at the Institute Pasteur has just been concluded. It was a truly exciting 3-day symposium with intriguing lectures and discussions on the latest and greatest science on nanoparticles and their possible nanomedical applications. The symposium was also the forum for presentation of over 60 posters and a collection of scientific instruments comprising a small but interesting exhibition. The event additionally presented an opportunity of networking and exchanging views with scientists from other EU funded projects. The participation of numerous (> 280) scientists, especially young researchers and students, made the symposium a big success.
October 21, 2015
The e-version of the elegant Cyclon Hit Newsletter has been published. In the newsletter one can have a short overview of the threatening issue of bacterial infections, mini introductions on nanocarriers for antibacterial agents, selected research highlights and early results as well as all network activities and output since the begining of the project.
October 9 &11, 2015
More than 150 people including young students from schools and colleges participated in the event. The students learned to prepare « green» nanoparticles and participated in numerous discussions about nanomedicine and resistant bacteria.
A CyclonHit poster was presented by MC Fellows E. Pancani and G. Salazano.
October 5, 2015
NEW e-LECTURE in the E-class collection: Lecture 1-Cyclodextrins: History and Chemistry, prepared by Drs. Eva Fenyvesi and István Puskás of patner Cyclolab SA, Budapest. Click and enjoy!
In the E-classes tab (left pane) five extremely interesting lectures can now be found. Watching all five videos significantly deepens our knowledge on cyclodextrins and their pharmaceutical applications.
September 14, 2015
REMINDER- The next International event of Cyclon Hit, the 2nd Summer School and Workshop, Advances in Nanoparticulate carriers: Applications in diseases and infections is approaching. Click to see the scientific program and to register!
September 14, 2015
The issues of Cyclodextrin news prepared by the CycloLab SA scientists, are regularly updated in this site and can be found in the Journals tab, on the left. Now the August issue is published.
July 21, 2015
The June-July issue of Cyclodextrin news is now available from Cyclolab SA.
May 27, 2015
Interesting to all! A collection of articles, reviews and books on Antimicrobial Resistance are free to access from across the Royal Society of Chemistry journal portfolio until June 18.
May 14, 2015
Click to link into CycloLab's all Cyclodextrin News Issues
May 8, 2015
UPCOMING CycloN-HIT EVENT- SUMMER SCHOOL AND WORKSHOP: Advances in nanoparticulatecarriers: Applications in diseases and infections: Paris, France October 19-21, 2015.
Pharmaceutical Applications of Cyclodextrins
WATCH the E-class Videos uploaded. Excellent presentations have been prepared by Professor Thorsteinn Loftsson, University of Iceland, a world expert on the subject.
April 27, 2015
Post-Doctoral Position: The Institute of Molecular Sciences, University Paris Sud, Orsay, is seeking a motivated fellow for a two-years Post-Doctoral Position in the frame of the Cyclon-Hit project.
Deadline for application: June 1st, 2015.Anticipated starting date: September 1st, 2015 or according to agreement. Click here for details.
April 20, 2015
Post-doctoral position: The Intitut Pasteur de Lille CIIL - Center of Infection and Immunity of Lille, France is seeking a suitable candidate to fill a three-years Post-Doctoral Position for the CycloN-Hit project (and an ERC Grant INTRACELLTB). Click here for details
April 7, 2015
Post-Doctoral Position: The Laboartory of Structural and Supramolecular Chemistry, Institute of Nanoscience & Nanotechnology, NCSR "Demokritos", Athens, Greece, is seeking a suitable candidate to fill a one-year Post-Doctoral Position for the Cyclon-Hit project.Deadline: May 15, 2015.Anticipated starting date: June 15, 2015 or according to contract. Click here for details.
March 12, 2015
Upcoming Cyclon Hit Budapest meeting and Workshop: click here for hotel booking and general directions
March 5, 2015
Pharmaceutical Applications of Cyclodextrins
Free E-class Videos are now uploaded. Excellent presentations have been prepared by Professor Thorsteinn Loftsson, a world expert on the subject. More e-classes will follow!
March 5, 2015
The next European Cyclodextrin Conference, will be held in Lille, France, October 7 through October 9, 2015.
Deadline for abstarct submission is May 4, 2015.
March 5, 2015
The next CycloN Hit meeting and Workshop will be held in Budapest May 7 & 8, 2015.
Follow this page for more details.
February 13, 2015
The January issue of Cyclodextrin News is now available from CycloLab with the latest scientific literature on cyclodextrins. Main article is about "Cyclodextrins in artificial fertilization of animal", by Dr. Eva Fenyvesi.
Also check out the latest news related to cyclodextrins, as compiled by Cyclolab
February 2, 2015
The 1st CYCLON-HIT article in now published on-line in Scientific Reports
A "green" strategy to construct non-covalent, stable and bioactive coatings on porous MOF nanoparticles.
V. Agostoni, P. Hocajada, M. Noiray, M. Malanga, A. Aykac, L. Jicsinsky, A. Vargas-Berenguel, N. Semiramoth, S. Daoud-Mahammed, V. Nicolas, C. Martineau, F. Taulelle, J. Vigneron, A. Etcherberry, C. Serre, R. Gref.
January 8, 2015
HAPPY NEW YEAR!!
The latest issue of Cyclodextrin News is now available from CycloLab with the latest scientific literature on cyclodextrins.
November 5, 2014
The October issue of Cyclodextrin News is now available from CycloLab. The editorial points out the notable increase in patents related to Cyclodextrins.
October 20, 2014
The 1st Summer School of CycloN Hit "Nanomaterials for Bioapplications: focus on antimicrobial research" was successully concluded on October 2nd, 2014. The numerous participants enjoyed lectures and labs both at NCSR "Demokritos" and the Hellenic Pasteur Institute. The school was followed by the CycloN Hit Scientifific meeting, held at the Hellenic Pasteur Institute on October 3, 2014.
October 1, 2014
September 29, 2014
September 8, 2014
The 1st Summer School of CycloN Hit will be held in Athens, Greece, September 30 - October 2, 2014 .
To see the program and register to attend the school click here.
August 21, 2014
June 25, 2014
The 1st Summer School of CycloN Hit "Nanomaterials for bio-applications: focus on antimicrobial research" will be coorganized by NCSR "Demokritos" and the Hellenic Pasteur Institute, from September 30 to October 2, 2014 in Athens, Greece.
June 16, 2014
PhD Student (Early Stage Researcher) position is now open at the University of Catania, Department of Drug Sciences. Deadline is July 10, 2014.
June 16, 2014
March 5, 2014
The Cyclon-Hit kickoff meeting was held on Monday, March 3rd at the CNRS campus, in Gif sur Yvette, Paris France. The CycloN Hit consortium is now in full operation.